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Det er hjernen, der er kommandocentralen i samspillet, og den indeholder flere milliarder nerveceller. Disse celler styrer alle impulser, og kroppens funktioner bliver varetaget af bestemte steder i hjernen. Man starter oftest den smertestillende behandling med et svagt virkende middel, hvis ikke smerterne allerede er blevet stærke.Den enkelte e
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